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<p class="MsoNormal">Hi All,<o:p></o:p></p>
<p class="MsoNormal">A fellowship is available for a student (holding a MS degree) or recent graduate (MS or PhD) to investigate ambient air inhalation risk at EPA in Research Triangle Park, NC. Details are available at
<a href="https://www.zintellect.com/Opportunity/Details/EPA-ORD-CCTE-CCED-2024-04">
https://www.zintellect.com/Opportunity/Details/EPA-ORD-CCTE-CCED-2024-04</a>.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="mso-margin-bottom-alt:auto;background:white"><b><u><span style="font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#131313;mso-ligatures:none">Research Project</span></u></b><b><span style="font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#131313;mso-ligatures:none">: </span></b><span style="font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#131313;mso-ligatures:none">The
EPA Center for Computational Toxicology and Exposure (CCTE) is responsible for developing new computational tools and providing quantitative analysis for improving public health and environmental risk assessments and regulatory decisions pertaining to chemical
safety. In addition, the EPA Center for Environmental Measurement and Modeling (CEMMS) develops tools for prediction of ambient air quality in support of the Clean Air Act. The research participant will join a high-performing, multi-center team including modelers,
programmers, wet lab scientists, and public health decision makers. The participant will be mentored by John Wambaugh and Havala Pye. The research participant will have latitude in exercising independent initiative and judgment to participate and develop additional
research projects commensurate with the level of training. <o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-bottom-alt:auto;background:white"><span style="font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#131313;mso-ligatures:none">Under the guidance of a mentor, the research participant will evaluate new approach methods
(NAMs) for potentially assessing human health risk from air pollutants. People inhale roughly 2,000 gallons of air a day. Within that air are a myriad of emitted compounds and their oxidation products. Known pollutants are combined with ambient exposure concentrations
to calculate risk at the census tract level as part of EPA's AirToxScreen. Some fraction of inhaled risk is not captured by current methods because there are known compounds in air for which we do not have routine methods to estimate risk. Further, some airborne
pollutants have yet to be sufficiently characterized in terms of health effects. Over the past two decades in vitro-based NAMs have been developed for otherwise data-poor chemicals. These NAMs can help assess the potential hazard and link exposure to tissue
concentrations (that is, toxicokinetics). NAMs were previously limited to chemicals amenable to in vitro testing (in particular, only semi- or non-volatile compounds). However, there have been sufficient NAM data collected to allow tools for relating chemical
structure to key hazard and toxicokinetic properties. The research participant will estimate risk for understudied air pollutants by combining computational models for predicting airborne chemical concentration, mathematical models for relating inhaled concentration
to human plasma levels, and structure-based models for chemical toxicity. The research participant will evaluate the usefulness of these tools for hazardous air pollutants that have no other available data.<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-bottom-alt:auto;background:white"><span style="font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#131313;mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal" style="mso-margin-bottom-alt:auto;background:white"><span style="font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#131313;mso-ligatures:none">Havala Pye and John Wambaugh<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="mso-ligatures:none">Havala Olson Taylor Pye, Ph.D.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none">Physical Scientist<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none">Office of Research and Development<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none">U.S. Environmental Protection Agency<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none">Research Triangle Park, North Carolina<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none">Email: <a href="mailto:Pye.Havala@epa.gov">
<span style="color:#0563C1">Pye.Havala@epa.gov</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ligatures:none">havalapye.wordpress.com<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="mso-margin-bottom-alt:auto;background:white"><span style="font-size:11.5pt;font-family:"Helvetica",sans-serif;color:#131313;mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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