<div dir="ltr"><p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">Dear CEDAR Colleagues,</span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black"> </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">We would like to invite
the CEDAR community to propose new Grand Challenge</span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">(GC) topics to be
initiated at the 2022 CEDAR Workshop. </span><span style="font-size:12pt;color:rgb(42,42,42);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><b>Grand Challenge (GC) workshop</b> addresses urgent, overarching
questions which require a multiyear effort and are of high importance to the
CEDAR community. </span><span style="font-size:12pt;color:black"><b>One new Grand Challenge workshop will be selected in 2022.</b></span><span style="font-size:12pt;color:rgb(42,42,42);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:rgb(42,42,42);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:rgb(42,42,42);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">GC workshops are 3 year efforts and should be
organized by a diverse team of conveners with a clear schedule and specific
goals and topics for the 3 years. In the first year a GC workshop will
introduce the topic to the CEDAR community in the plenary session and provide
updates in the year 2 & 3 with a summary after year 3. </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:rgb(42,42,42);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:rgb(42,42,42);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Please read the workshop proposal guidelines at
</span><a href="https://cedarscience.org/workshop-proposal-guidelines" style="color:rgb(5,99,193)"><span style="font-size:12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">https://cedarscience.org/workshop-proposal-guidelines</span></a><span style="font-size:12pt;color:rgb(42,42,42);background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> to prepare for your GC workshop proposal
submission. </span><span style="font-size:12pt;color:black"></span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black"> </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">A list of current and past
GC workshops can be found at <a href="https://cedarscience.org/grand-challenge-workshops">https://cedarscience.org/grand-challenge-workshops</a></span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black"> </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black"><b>Proposals for a Grand
Challenge workshop can be submitted online by March 14, 2022 at </b></span><a href="https://cedarscience.org/workshop-proposal-submission" style="font-family:Arial,Helvetica,sans-serif;font-size:small"><b>the workshop proposal submission site</b></a></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black"> </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">We look forward to
receiving your proposals and seeing you at this</span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">year’s CEDAR Workshop!</span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black"> </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">Sincerely, </span></p>

<p class="MsoNormal" style="margin:0in;line-height:normal;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:12pt;color:black">Astrid Maute on behalf of the CEDAR
Science Steering Committee</span></p><div><br></div></div>